Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1 alpha Stability in Aerobic Conditions
Stephen P Burr, Ana SH Costa, Guinevere L Grice, Richard T Timms, Ian T Lobb, Peter Freisinger, Roger B Dodd, Gordon Dougan, Paul J Lehner, Christian Frezza, James A Nathan
Cell Metabolism | CELL PRESS | Published : 2016
Awarded by Wellcome Trust
Awarded by Medical Research Council
We thank Patrick Maxwell, Mike Murphy, and the J.A.N. laboratory for their helpful discussions and Alison Schuldt for help with the manuscript. We also thank Marco Sciacovelli for his help in designing the bioenergetic profiling experiments. Johannes Mayer kindly provided the patient fibroblasts with mutations in Fe-S biosynthesis and lipoic acid synthesis. This work was supported by a Wellcome Trust Senior Clinical Research Fellowship to J.A.N. (102770/Z/13/Z), Wellcome Trust Principal Research Fellowship to P.J.L. (084957/Z/08/Z), and the Medical Research Council (A.S.H.C. and C.F.). The Cambridge Institute for Medical Research is in receipt of a Wellcome Trust Strategic Award (100140).