Journal article
Dengue in adults admitted to a referral hospital in Hanoi, Vietnam
WR Taylor, A Fox, KT Pham, HNM Le, NTH Tran, G Van Tran, BT Nguyen, M Van Nguyen, LT Nguyen, S Yacoub, HTT Nguyen, HH Nguyen, HD Nguyen, H Wertheim, P Horby, J Farrar, LTM Trinh, K Van Nguyen
American Journal of Tropical Medicine and Hygiene | AMER SOC TROP MED & HYGIENE | Published : 2015
Abstract
Knowledge of adult dengue virus (DENV) infection from Hanoi, Vietnam, is limited. In 2008, we prospectively studied 143 (77 male) confirmed (nonstructural 1 antigen enzyme-linked immunosorbent assay [ELISA], DENV polymerase chain reaction, paired serology) adult dengue patients of median age 23.5 (range 16-72) years. They were admitted to the National Hospital for Tropical Diseases, Hanoi, on median illness day (D) 5 (range 1-8). By D8, 141 (98.6%) were afebrile. Platelet counts and hematocrit (median, interquartile range [IQR]) nadired and peaked on D5 and D4, respectively: 40,000/μL (10,000-109,000/μL), 43.4% (34.9-49.7%). Four (2.8%) patients had severe dengue: 1) D10 shock (N = 1) and 2)..
View full abstractGrants
Awarded by European Commission
Funding Acknowledgements
The study was funded from the core grant of the Viet Nam Wellcome Trust Major Overseas Programme. At the time of the study, Walter R. Taylor was supported by the South East Asian Infectious Diseases Clinical Research Network. Annette Fox was supported by the European Union FP7 project "European Management Platform for Emerging and Re-emerging Infectious Disease Entities (EMPERIE, no. 223498)."