Genetic and Environmental Factors in Invasive Cervical Cancer: Design and Methods of a Classical Twin Study
Dorothy A Machalek, John D Wark, Sepehr N Tabrizi, John L Hopper, Minh Bui, Gillian S Dite, Alyssa M Cornall, Marian Pitts, Dorota Gertig, Bircan Erbas, Suzanne M Garland
Twin Research and Human Genetics | CAMBRIDGE UNIV PRESS | Published : 2017
BACKGROUND: Persistent high-risk human papillomavirus (HPV) infection is a necessary prerequisite for development of cervical cancer and its precursor lesion, high-grade squamous intraepithelial lesion (HSIL). However, HPV infection is not sufficient to drive this process, and genetic and environmental factors may also play a role. METHODS/DESIGN: The Cervical Cancer, Genetics and Environment Twin Study was established to investigate the environmental and genetic influences on variation in susceptibility to cervical pre-cancer in 25- to 69-year-old monozygotic (MZ) and dizygotic (DZ) twins recruited through the Australian Twin Registry. Reviews of Papanicolaou (Pap) screening histories were ..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by Cancer Australia grant
Funding for this study was provided by the National Health and Medical Research Council project grant (509002) and Cancer Australia grant (1008811). The CeCaGeEn Study Group includes Suzanne M. Garland, John D Wark, Sepehr Tabrizi, John L. Hopper, Dorota Gertig, Marian Pitts, Bircan Erbas, Ian Frazer, Michael McCullough, Dorothy A. Machalek, Minh Bui, Alyssa Cornall, Samuel Phillips, and Gillian S. Dite. We sincerely thank the following research assistants and project managers over the years; Gemma Christie, Elya Moore, Nicole Taylor, Amanda Richardson, Nicole Lister, Juliana Tasevska, Anna Debenham, Melissa Sullivan, Debra Tamvakis, Melissa Yow, and Houda Abdo. Also, we express our thanks to staff of the Australian Twin Registry and Victorian Cytology Registry and other pathology laboratories for retrieving slides. Finally, we thank all the participants without whom the study could not have happened.