Journal article
Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region
X Castellsagué, KA Ault, FX Bosch, D Brown, J Cuzick, DG Ferris, EA Joura, SM Garland, AR Giuliano, M Hernandez-Avila, W Huh, OE Iversen, SK Kjaer, J Luna, J Monsonego, N Muñoz, E Myers, J Paavonen, P Pitisuttihum, M Steben Show all
Papillomavirus Research | ELSEVIER | Published : 2016
Abstract
Background: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region. Methods: Women ages 15-26 and 24-45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. Results: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type pr..
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Awarded by National Institutes of Health
Funding Acknowledgements
This study was funded by Merck and Co., Inc., Kenilworth, NJ (ClinicalTrials.gov: NCT00092521, NCT00092534, and NCT00090220). This systematic review was designed, managed, and analyzed jointly by authors employed by Merck & Co. and external authors who were not paid for their work.