Introduction, Interconversion and Removal of Boron Protecting Groups

Abstract

Boronic acid protecting groups have revolutionized the use of organoborons in synthetic chemistry, enabling organoboron functional groups to be carried through multistep protocols, no longer limited to introduction of boron at a late stage or subject to immediate transformation. The development of novel B-protecting groups and methods for their orthogonal introduction and deprotection has enabled chemoselective transformations of organoboron compounds, including those with multiple organoboron functional groups. The arsenal of B-protecting groups and methods for their introduction, interconversion and removal is outlined in this chapter.