Journal article
The Eye As a Biomarker for Alzheimer's Disease
Jeremiah KH Lim, Qiao-Xin Li, Zheng He, Algis J Vingrys, Vickie HY Wong, Nicolas Currier, Jamie Mullen, Bang V Bui, Christine TO Nguyen
FRONTIERS IN NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2016
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and eventual death. It is the leading cause of dementia and the number of cases are projected to rise in the next few decades. Pathological hallmarks of AD include the presence of hyperphosphorylated tau and amyloid protein deposition. Currently, these pathological biomarkers are detected either through cerebrospinal fluid analysis, brain imaging or post-mortem. Though effective, these methods are not widely available due to issues such as the difficulty in acquiring samples, lack of infrastructure or high cost. Given that the eye possesses clear optics and shares many neural and vascular similarities ..
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Grants
Awarded by Australian Research Council Linkage grant
Funding Acknowledgements
CN, BB, AV, JM, (all authors), Samantha Budd Haeberlein, are joint investigators on an Australian Research Council Linkage grant LP160100126. BB is a sole investigator on Australian Research Council Linkage grant FT130100338.