Journal article

The Eye As a Biomarker for Alzheimer's Disease

Jeremiah KH Lim, Qiao-Xin Li, Zheng He, Algis J Vingrys, Vickie HY Wong, Nicolas Currier, Jamie Mullen, Bang V Bui, Christine TO Nguyen

FRONTIERS IN NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2016

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and eventual death. It is the leading cause of dementia and the number of cases are projected to rise in the next few decades. Pathological hallmarks of AD include the presence of hyperphosphorylated tau and amyloid protein deposition. Currently, these pathological biomarkers are detected either through cerebrospinal fluid analysis, brain imaging or post-mortem. Though effective, these methods are not widely available due to issues such as the difficulty in acquiring samples, lack of infrastructure or high cost. Given that the eye possesses clear optics and shares many neural and vascular similarities ..

View full abstract