Journal article

Comparison of creatinine and cystatin C based eGFR in the estimation of glomerular filtration rate in Indigenous Australians: The eGFR Study

Elizabeth LM Barr, Louise J Maple-Brown, Federica Barzi, Jaquelyne T Hughes, George Jerums, Elif I Ekinci, Andrew G Ellis, Graham RD Jones, Paul D Lawton, Cherian Sajiv, Sandawana W Majoni, Alex DH Brown, Wendy E Hoy, Kerin O'Dea, Alan Cass, Richard J MacIsaac

CLINICAL BIOCHEMISTRY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017

Abstract

BACKGROUND: The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation that combines creatinine and cystatin C is superior to equations that include either measure alone in estimating glomerular filtration rate (GFR). However, whether cystatin C can provide any additional benefits in estimating GFR for Indigenous Australians, a population at high risk of end-stage kidney disease (ESKD) is unknown. METHODS: Using a cross-sectional analysis from the eGFR Study of 654 Indigenous Australians at high risk of ESKD, eGFR was calculated using the CKD-EPI equations for serum creatinine (eGFRcr), cystatin C (eGFRcysC) and combined creatinine and cystatin C (eGFRcysC+cr). Reference GFR (m..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by National Health and Medical Research Council (NHMRC) Training Research Fellowship


Awarded by NHMRC Early Career Fellowship: Health Professional Research Fellowship


Awarded by NHMRC


Funding Acknowledgements

The eGFR Study was funded by the National Health and Medical Research Council of Australia (NHMRC, Project Grants #545202 and #1021460), with additional support from Kidney Health Australia, NHMRC Program Grant (#631947), the Colonial Foundation, Diabetes Australia Research Trust, Rebecca L. Cooper Foundation and SeaSwift, Thursday Island. ELMB was supported by a National Health and Medical Research Council (NHMRC) Training Research Fellowship (#APP1016612); LJM-B was supported by a NHMRC Fellowship (#605837) and NHMRC Practitioner Fellowship (#1078477); FB was supported by NHMRC Program Grant (#631947); JTH was supported by NHMRC Fellowship (#1092576) and RACP Jacquot Research Establishment Award; PDL was supported by NHMRC Scholarship (#1038721) and RACP Jacquot Research Establishment Award; EIE was supported by an NHMRC Early Career Fellowship: Health Professional Research Fellowship (Part Time, #1054312), Viertel Clinical Investigatorship and a RACP JDRF Research Establishment Fellowship. AC holds a NHMRC Principal Research Fellowship (#1027204), and WH directs the NHMRC funded Centre for Research Excellence in Chronic Kidney Disease (#1079502). ADHB is supported by a Viertel Senior Medical Research Fellowship. Funding bodies had no role in the study design, in the collection, analysis or interpretation of data, in the writing of the manuscript or the decision to submit the manuscript for publication.