Journal article

DIVERSITY OF THE OSTEOBLASTIC PHENOTYPE

GA RODAN, JK HEATH, KG YOON, M NODA, SB RODAN

CIBA FOUNDATION SYMPOSIA | JOHN WILEY & SONS LTD | Published : 1988

Abstract

Studies of bone cells in culture have raised two salient questions: are the findings representative of the in vivo situation and can the conflicting data from different cell models be reconciled? Review of the literature indicates that all osteoblastic cells, defined by their origin or by their ability to produce mineralized matrix, have a few common properties: production of type I collagen; increased alkaline phosphatase activity; and parathyroid hormone-stimulated adenylate cyclase. Other features, such as osteocalcin and prostaglandin E production and the response to prostaglandin E, are selectively expressed by certain cell types. Pilot studies on mRNA levels of 'bone proteins' in devel..

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