Journal article

BIOCHEMICAL AND AUTORADIOGRAPHICAL EVIDENCE THAT ANTERIOR MANDIBULAR DISPLACEMENT IN THE YOUNG GROWING-RAT DOES NOT STIMULATE CELL-PROLIFERATION OR MATRIX FORMATION AT THE MANDIBULAR CONDYLE

DHTK TEWSON, JK HEATH, MC MEIKLE

ARCHIVES OF ORAL BIOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 1988

Abstract

A removable bite plate was used to induce forward mandibular displacement in four-week-old rats for 10 h/day for 1, 3, 7, 11 and 14 days. The animals were killed and the condylar explants pulsed in vitro for 6 h with either [3H]-thymidine or [3H]-proline or 35SO(2-)4. The specific activity of radio-isotope incorporation was expressed as dis/min per microgram DNA, dis/min per mg protein and dis/min per microgram sulphated glycosaminoglycans (GAG). [3H]-thymidine autoradiography was also used in a 14-day experiment to establish a radioactive index (labelled cells per 1000 cells counted) for the anterior, middle and posterior regions of the condyle. There was no significant alteration in either..

View full abstract