Journal article

Lifetime alcohol intake is associated with an increased risk of KRAS plus and BRAF-/KRAS- but not BRAF plus colorectal cancer

Harindra Jayasekara, Robert J MacInnis, Elizabeth J Williamson, Allison M Hodge, Mark Clendenning, Christophe Rosty, Rhiannon Walters, Robin Room, Melissa C Southey, Mark A Jenkins, Roger L Milne, John L Hopper, Graham G Giles, Daniel D Buchanan, Dallas R English



Ethanol in alcoholic beverages is a causative agent for colorectal cancer. Colorectal cancer is a biologically heterogeneous disease, and molecular subtypes defined by the presence of somatic mutations in BRAF and KRAS are known to exist. We examined associations between lifetime alcohol intake and molecular and anatomic subtypes of colorectal cancer. We calculated usual alcohol intake for 10-year periods from age 20 using recalled frequency and quantity of beverage-specific consumption for 38,149 participants aged 40-69 years from the Melbourne Collaborative Cohort Study. Cox regression was performed to derive hazard ratios (HRs) and 95% confidence intervals (CIs) for the association betwee..

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Awarded by Australian National Health and Medical Research Council (MCCS)

Funding Acknowledgements

Grant sponsor: VicHealth and Cancer Council Victoria (MCCS cohort recruitment); Grant sponsor: Australian National Health and Medical Research Council (MCCS); Grant numbers: 209057, 251553 and 504711; Grant sponsor: Cancer Council Victoria (infrastructure); Grant sponsor: NHMRC Senior Research Fellow (M.A.J.); Grant sponsor: NHMRC Senior Principal Research Fellow (J.L.H.); Grant sponsor: University of Melbourne Research at Melbourne Accelerator Program (R@MAP) Senior Research Fellow (D.D.B.); Grant sponsor: Victorian Department of Health and the Foundation for Alcohol Research and Education (R.R. position)