Journal article

Influence of Population Demography and Immunization History on the Impact of an Antenatal Pertussis Program

Patricia Therese Campbell, Jodie McVernon, Peter McIntyre, Nicholas Geard

CLINICAL INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2016

Abstract

BACKGROUND:  Antenatal pertussis vaccination is being considered as a means to reduce the burden of infant pertussis in low- and middle-income countries (LMICs), but its likely impact in such settings is yet to be quantified. METHODS:  An individual-based model was used to simulate the demographic structure and dynamics of a population with characteristics similar to those of LMICs. Transmission of pertussis within this population was simulated to capture the incidence of infection in (1) the absence of vaccination; (2) with a primary course only (three doses of diphtheria, tetanus, and pertussis vaccines [DTP3] commencing in 1985, 1995, or 2005 at 20%, 50%, or 80% coverage); and (3) with th..

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