Influence of population demography and immunization history on the impact of an antenatal pertussis program

PT Campbell; J McVernon; P McIntyre; N Geard

Journal article

Influence of population demography and immunization history on the impact of an antenatal pertussis program

PT Campbell, J McVernon, P McIntyre, N Geard

Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2016

DOI: 10.1093/cid/ciw520

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Abstract

Background. Antenatal pertussis vaccination is being considered as a means to reduce the burden of infant pertussis in low-and middle-income countries (LMICs), but its likely impact in such settings is yet to be quantified. Methods. An individual-based model was used to simulate the demographic structure and dynamics of a population with characteristics similar to those of LMICs. Transmission of pertussis within this population was simulated to capture the incidence of infection in (1) the absence of vaccination; (2) with a primary course only (three doses of diphtheria, tetanus, and pertussis vaccines [DTP3] commencing in 1985, 1995, or 2005 at 20%, 50%, or 80%coverage); and (3) with the ad..

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University of Melbourne Researchers

Patricia Campbell Author

Jodie McVernon Author

Nic Geard Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the Australian Research Council (grant numbers DP110101758 to J. M., and DE130100660 to N. G.) and the National Health and Medical Research Council (NHMRC) (grant numbers 1078068 to N. G. and J. M., and CDF1061321 to J. M.).