Enhancing PET Signal at Target Tissue in Vivo: Dendritic and Multimeric Tris(hydroxypyridinone) Conjugates for Molecular Imaging of alpha(v)beta(3) Integrin Expression with Gallium-68
Cinzia Imberti, Samantha YA Terry, Carleen Cullinane, Fiona Clarke, Georgina H Cornish, Nisha K Ramakrishnan, Peter Roselt, Andrew P Cope, Rodney J Hicks, Philip J Blower, Michelle T Ma
Bioconjugate Chemistry | AMER CHEMICAL SOC | Published : 2017
Awarded by European Union
Awarded by Arthritis Research UK
Awarded by EPSRC
M.T.M. acknowledges the support of the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement number 299009, and the Royal Society of Chemistry through a Researcher Mobility Fellowship. C.I. acknowledges the NIHR Biomedical Research Centre for a PhD studentship. G.H.C., F.C and A.P.C. acknowledge the support of Arthritis Research UK under grant number 20525. We thank Wayne Noonan, Kerry Ardley, and Rachael Walker for expert technical support. We thank Cristina Sanchez-Blanco for collecting the arthritogenic serum from KRN+ x NOD offspring. This research was supported by the Centre of Excellence in Medical Engineering Centre funded by the Wellcome Trust and EPSRC (WT088641/Z/09/Z), the KCL and UCL Comprehensive Cancer Imaging Centre funded by CRUK and EPSRC in association with the MRC and DoH (England), and by the NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the DoH.