Bionano Interaction Study on Antimicrobial Star-Shaped Peptide Polymer Nanoparticles
Shu J Lam, Edgar HH Wong, Neil M O'Brien-Simpson, Namfon Pantarat, Anton Blencowe, Eric C Reynolds, Greg G Qiao
ACS Applied Materials & Interfaces | AMER CHEMICAL SOC | Published : 2016
'Structurally nanoengineered antimicrobial peptide polymers' (SNAPPs), in the form of star-shaped peptide polymer nanoparticles, have been recently demonstrated as a new class of antimicrobial agents with superior in vitro and in vivo efficacy against Gram-negative pathogens, including multidrug-resistant species. Herein, we present a detailed bionano interaction study on SNAPPs by assessing their antimicrobial activities against several Gram-negative bacteria in complex biological matrices. Simulated body fluid and animal serum were used as test media to reveal factors that influence the antimicrobial efficacy of SNAPPs. With the exception of Acinetobacter baumannii, the presence of divalen..View full abstract
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Awarded by Australian Research Council
G.G.Q, acknowledges the Australian Research Council under the Future Fellowship (FT110100411) scheme for financial support of this work. E.C.R. acknowledges the Australian Government, Department of Industry, Innovation and Science for financial support. S.J.L. acknowledges the Australian Government for providing an International Postgraduate Research Scholarship (IPRS) and an Australian Postgraduate Award (APAInt).