Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Clare Y Slaney; Bianca von Scheidt; Alexander J Davenport; Paul A Beavis; Jennifer A Westwood; Sherly Mardiana; David C Tscharke; Sarah Ellis; H Miles Prince; Joseph A Trapani; Ricky W Johnstone; Mark J Smyth; Michele W Teng; Aesha Ali; Zhiya Yu; Steven A Rosenberg; Nicholas P Restifo; Paul Neeson; Phillip K Darcy; Michael H Kershaw

Journal article

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Clare Y Slaney, Bianca von Scheidt, Alexander J Davenport, Paul A Beavis, Jennifer A Westwood, Sherly Mardiana, David C Tscharke, Sarah Ellis, H Miles Prince, Joseph A Trapani, Ricky W Johnstone, Mark J Smyth, Michele W Teng, Aesha Ali, Zhiya Yu, Steven A Rosenberg, Nicholas P Restifo, Paul Neeson, Phillip K Darcy, Michael H Kershaw

Clinical Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2017

DOI: 10.1158/1078-0432.CCR-16-1860

University of Melbourne Researchers

Phillip Darcy Author The Sir Peter MacCallum Department of Oncology

Sarah Ellis Author The Sir Peter MacCallum Department of Oncology

Clare Slaney Author The Sir Peter MacCallum Department of Oncology

Paul Neeson Author The Sir Peter MacCallum Department of Oncology

Ricky Johnstone Author The Sir Peter MacCallum Department of Oncology

Related Projects (2)

Adoptive Cell Transfer Incorporating Vaccination (Activ) Therapy For Cancer

We have made a breakthrough in a new treatment for cancer that can destroy large tumours in mice. The treatment involves a transfusion of wh..

Attacking Cancer Using A Unified Immune System

Grants

Awarded by Cancer Council of Victoria, Australia

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

This work was supported by grants from the Cancer Council of Victoria, Australia (1066554), The Peter MacCallum Cancer Center Foundation, and the National Health and Medical Research Council (NHMRC) of Australia (1103352). C.Y. Slaney and P. Beavis were supported by Postdoctoral Fellowships from the National Breast Cancer Foundation of Australia. A.J. Davenport and S. Mardiana received Postgraduate Scholarships from the Fight Cancer Foundation and University of Melbourne respectively. R.W. Johnstone and M.J. Smyth were supported by Senior Principal Research Fellowships from the NHMRC. M.H. Kershaw and P.K. Darcy were supported by Senior Research Fellowships from the NHMRC. S. Ellis was supported by a New Investigator Grant from the NHMRC.