Chronic postsurgical pain in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial

MTV Chan; PJ Peyton; PS Myles; K Leslie; N Buckley; J Kasza; MJ Paech; WS Beattie; DI Sessler; A Forbes; S Wallace; Y Chen; Y Tian; WKK Wu; W Galagher; C Farrington; A Ditoro; S Baulch; D Fahlbusch; D Crump; R Bulach; D Bryant; E O'Loughlin; V Mitteregger; S Bolsin; C Osborne; R McRae; M Backstrom; M Reeves; G Thompson; R Cotter; S March; T McCulloch; B Silbert; S Said; R Halliwell; J Cope; A Jefferies; N Badner; T Tidy; T Schricker; R Latterman; J Carroll; M Jacka; C Bryden; MWY Tsang; BCP Cheng; ACM Fong; LCY Chu; EGY Koo; N Mohd; LE Ming; C Wang; D Campbell; D McAllister; R Kennedy; S Walker; S Olliff; A Eldawlatly; T Alzahrani; N Chua; G Haller; I Pichon; J Cupitt; A Brennan; P Balaji; G Kunst; G Rousseau; R Sneyd; H McMillan; J Nightingale; M Dickinson; T Saran; I Parkinson; B Subramaniam; V Banner-Godspeed; A Kurz; B Hesler; J Liu; A Fu; C Egan; K Cummings; N Graham; D Obal; E Cooke

Journal article

Chronic postsurgical pain in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial

MTV Chan, PJ Peyton, PS Myles, K Leslie, N Buckley, J Kasza, MJ Paech, WS Beattie, DI Sessler, A Forbes, S Wallace, Y Chen, Y Tian, WKK Wu, W Galagher, C Farrington, A Ditoro, S Baulch, D Fahlbusch, D Crump Show all

British Journal of Anaesthesia | ELSEVIER SCI LTD | Published : 2016

DOI: 10.1093/bja/aew338

Abstract

Background. Previous animal and clinical studies showed that nitrous oxide may produce long-termanalgesia. The aim of this study was to evaluate the effect of nitrous oxide in preventing chronic postsurgical pain. We also explored whether methylenetetrahydrofolate reductase gene polymorphisms (1298A>C, 667C>T) would enhance nitrous oxide analgesia. Methods. We conducted a telephone interview at 12 months after surgery on 2924 (41.1%) patients enrolled in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia-II trial. Pain at the wound site was recorded using the modified brief pain inventory and the neuropathic pain questionnaire. General health status was measured using the EQ-..

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University of Melbourne Researchers

Philip Peyton Author

Kate Leslie Author

Brendan Silbert Author

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was supported by a project grant (11121051) from Health and Medical Research Fund, Hong Kong Special Administrative Region, China and project grants (10/014 and 12/ 008) from the Anaesthesia and Pain Medicine Foundation, Australian and New Zealand College of Anaesthetists. The ENIGMA-II Trial was supported by a project grant (435015) from the Australian Government National Health and Medical Research Council and a project grant from General Research Fund (461409), Research Grants Council, Hong Kong Special Administrative Region, China. P.S.M. is supported by the National Health and Medical Research Council, Practitioner Fellowship scheme.