Journal article

Interactions between circulating nanoengineered polymer particles and extracellular matrix components in vitro

Julia A Braunger, Mattias Bjornmalm, Nathan A Isles, Jiwei Cui, Timothy MA Henderson, Andrea J O'Connor, Frank Caruso

BIOMATERIALS SCIENCE | ROYAL SOC CHEMISTRY | Published : 2017

Abstract

The extracellular matrix (ECM) that surrounds cells in vivo represents a biological barrier for nanomaterials in biomedicine. Herein, we present a system for investigating the interactions between circulating polymer particles and ECM components in vitro using a commercially available flow-based device. We use this system to show how material-dependent interactions of two different particle types-one assembled using poly(ethylene glycol) (PEG) and one prepared using poly(methacrylic acid) (PMA)-affect their interactions with basement membrane extracts during in vitro circulation, with PEG particles remaining in circulation longer than PMA particles. Further, by comparing macroporous hyaluron..

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Grants

Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by ARC under the Australian Laureate Fellowship


Funding Acknowledgements

This research was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project CE140100036) and funded by the ARC under the Australian Laureate Fellowship (FL120100030) scheme. This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF).