Journal article

Prediction of cortical responses to simultaneous electrical stimulation of the retina

Kerry J Halupka, Mohit N Shivdasani, Shaun L Cloherty, David B Grayden, Yan T Wong, Anthony N Burkitt, Hamish Meffin



OBJECTIVE: Simultaneous electrical stimulation of multiple electrodes has shown promise in diversifying the responses that can be elicited by retinal prostheses compared to interleaved single electrode stimulation. However, the effects of interactions between electrodes are not well understood and clinical trials with simultaneous stimulation have produced inconsistent results. We investigated the effects of multiple electrode stimulation of the retina by developing a model of cortical responses to retinal stimulation. APPROACH: Electrical stimuli consisting of temporally sparse, biphasic current pulses, with amplitudes sampled from a bi-dimensional Gaussian distribution, were simultaneously..

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Awarded by National Health and Medical Research Council, Australia (GNT)

Awarded by Australian Research Council

Funding Acknowledgements

The authors thank Penny Allen, Jonathan Yeoh, and Chi Luu for surgeries; Carla Abbott, Alice Brandli, Alexia Saunders, Michelle McPhedran, Alison Neil, Dimitra Stathopoulos, Stephanie Epp, and Ceara McGowan for experimental assistance and animal handling; Owen Burns and Vanessa Maxim for manufacturing of the electrodes; Evgeni Sergeev for technical assistance with stimulation software; and Thomas Spencer, Faith Lamont, Ali Almasi, Felix Aplin, Rosemary Cicione, and Ronald Leung for assistance with data collection. This research was supported by the Australian Research Council through its Special Research Initiative in Bionic Vision Science and Technology awarded to Bionic Vision Australia, the Bertalli Family Foundation to the Bionics Institute, and a project grant from the National Health and Medical Research Council, Australia (GNT# 1063093). The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Program. KJH was supported by an Australian Postgraduate Award through the Australian Government, and a postgraduate scholarship from the National Information and Communication Technology Australia ( NICTA is funded by the Australian Government as represented by the Department of Broadband, Communications and the Digital Economy ( and the Australian Research Council through the ICT Centre of Excellence program. ANB and YTW acknowledge support under the Australian Research Council's Discovery Projects funding scheme (Project DP140104533).