Evaluation of the Biocompatibility of Polypyrrole Implanted Subdurally in GAERS
Sebastien H Bauquier, Karen J McLean, Jonathan L Jiang, Ray C Boston, Alan Lai, Zhilian Yue, Simon E Moulton, Amy J Halliday, Gordon Wallace, Mark J Cook
MACROMOLECULAR BIOSCIENCE | WILEY-V C H VERLAG GMBH | Published : 2017
This blinded controlled prospective randomized study investigates the biocompatibility of polypyrrole (PPy) polymer that will be used for intracranial triggered release of anti-epileptic drugs (AEDs). Three by three millimeters PPy are implanted subdurally in six adult female genetic absence epilepsy rats from Strasbourg. Each rat has a polymer implanted on one side of the cortex and a sham craniotomy performed on the other side. After a period of seven weeks, rats are euthanized and parallel series of coronal sections are cut throughout the implant site. Four series of 15 sections are histological (hematoxylin and eosin) and immunohistochemically (neuron-specific nuclear protein, glial fibr..View full abstract
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Awarded by Australian Research Council (ARC) Centre of Excellence Scheme
Awarded by ARC
The authors gratefully acknowledge the sponsorship of the Victorian Government through its Science Technology and Innovation Initiative administered by the Department of Industry, Innovation and Regional Development. The authors wish to acknowledge funding from the Australian Research Council (ARC) Centre of Excellence Scheme (CE140100012), the use of facilities at the University of Wollongong Electron Microscopy Centre, support of the Australian National Fabrication Facility (ANFF)-Materials Node. Professor Gordon Wallace acknowledges the support of the ARC through an ARC Laureate Fellowship (FL110100196).