Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin-Weintraub sequence motif: Reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour
N Schindler, J Mayer, S Saenger, U Gimsa, C Walz, J Brenmoehl, D Ohde, E Wirthgen, A Tuchscherer, VC Russo, M Frank, T Kirschstein, F Metzger, A Hoeflich
Growth Hormone & IGF Research | CHURCHILL LIVINGSTONE | Published : 2017
Awarded by Deutsche Forschungsgemeinschaft
The authors are indebted to Luong Chau, Sabine Hinrichs, Marion Spitschak, the Team of the LIN Dummerstorf and Martina Pohlmann for excellent animal care and technical support. This work was supported by a grant from the Deutsche Forschungsgemeinschaft (DFG HO 2003/6-1). We further acknowledge generation of the transgenic mouse models used in our study by Tamara Holy and Prof. Eckhard Wolf (Institute of Molecular Animal Breeding, Gene Center, LMU Munich, Germany). The publication of this article was funded by the Open Access fund of the Leibniz Institute for Farm Animal Biology (FBN).