Journal article

Endometrial cancer risk prediction including serum-based biomarkers: results from the EPIC cohort

Renee T Fortner, Anika Huesing, Tilman Kuehn, Meric Konar, Kim Overvad, Anne Tjonneland, Louise Hansen, Marie-Christine Boutron-Ruault, Gianluca Severi, Agnes Fournier, Heiner Boeing, Antonia Trichopoulou, Vasiliki Benetou, Philippos Orfanos, Giovanna Masala, Claudia Agnoli, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, HB as Bueno-de-Mesquita Show all



Endometrial cancer risk prediction models including lifestyle, anthropometric and reproductive factors have limited discrimination. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors. Serum concentrations of sex steroid hormones, metabolic markers, growth factors, adipokines and cytokines we..

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Awarded by European Commission

Awarded by European Research Council

Awarded by Health Research Fund (FIS)


Awarded by Cancer Research UK

Awarded by Medical Research Council

Awarded by National Institute for Health Research

Funding Acknowledgements

Grant sponsor: European Commission's Seventh Framework Programme; Grant number: MC-IIF-623984; Grant sponsor: European Research Council; Grant number: ERC-2009-AdG 232997; Grant sponsor: Health Research Fund (FIS); Grant numbers: PI13/00061 (EPIC-Granada), PI13/01162 (EPIC-Murcia); Grant sponsor: ISCIII RETIC; Grant number: RD06/0020; Grant sponsor: Cancer Research UK; Grant number: 14136 (EPIC-Norfolk); C570/A16491 and C8221/A19170 (EPIC-Oxford); Grant sponsor: Medical Research Council; Grant number: 1000143 (EPIC-Norfolk), MR/M012190/1 (EPIC-Oxford); Grant sponsor: European Commission (DG-SANCO) and the International Agency for Research on Cancer; Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, Institut National de la Sante et de la Recherche Medicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway); Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skane and Vasterbotten (Sweden)