A Meta-Analysis Evaluating the Relationship between Aquatic Contaminants and Chironomid Larval Deformities in Laboratory Studies
Bryant S Gagliardi, Vincent J Pettigrove, Sara M Long, Ary A Hoffmann
Environmental Science and Technology | AMER CHEMICAL SOC | Published : 2016
Chironomid larval deformities have been widely investigated as an aquatic pollution toxicity end point. Field chironomid surveys often show a spatial association between contaminants and deformities, suggesting contaminants cause deformities. However, over 40 years of laboratory assays have not been able to confirm this causality. We therefore conducted a review of the literature and meta-analysis, in order to (A) assess whether trends across assays indicated dose-response effects, (B) characterize the consistency of results, and (C) investigate whether experimental issues and publication bias were contributing to inconsistency and/or reducing confidence in results. The experimental issues w..View full abstract
We thank Dr Philippa Griffin for assistance with the layout of Figure 1, and four anonymous reviewers for helpful comments on the manuscript. This research was funded by the Centre for Aquatic Pollution Identification and Management, The University of Melbourne.