Journal article

Ascaris phylogeny based on multiple whole mtDNA genomes

Peter Nejsuma, Mohamed BF Hawash, Martha Betson, J Russell Stothard, Robin B Gasser, Lee O Andersen

INFECTION GENETICS AND EVOLUTION | ELSEVIER | Published : 2017

Abstract

Ascaris lumbricoides and A. suum are two parasitic nematodes infecting humans and pigs, respectively. There has been considerable debate as to whether Ascaris in the two hosts should be considered a single or two separate species. Previous studies identified at least three major clusters (A, B and C) of human and pig Ascaris based on partial cox1 sequences. In the present study, we selected major haplotypes from these different clusters to characterize their whole mitochondrial genomes for phylogenetic analysis. We also undertook coalescent simulations to investigate the evolutionary history of the different Ascaris haplotypes. The topology of the phylogenetic tree based on complete mitochon..

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University of Melbourne Researchers

Grants

Awarded by Danish Agency for Science, Technology and Innovation


Awarded by Wellcome Trust


Funding Acknowledgements

This work was supported by a Danish Agency for Science, Technology and Innovation (271-09-0162) grant awarded to PN. RBG's research is funded mainly through grants from the Australian Research Council (ARC) and the National Health and Medical Research Council (NHMRC) of Australia. MB is supported by University of Surrey. The original analysis of the samples reported in Betson et al. (2014) was supported by the Wellcome Trust (grant 085440) and the Natural History Museum, London. Thanks to Helena Ngowi (Sokoine University of Agriculture, Tanzania), Ida-Hella Poulsen and Sofie Nissen (University of Copenhagen, Denmark) for providing worms.