Journal article

IFN- promoter polymorphisms do not affect QuantiFERON TB Gold In-Tube test results in a Canadian population.

S Kiazyk, L Larcombe, C Lopez, S Matyas, C Mesa, P Orr, J Juno, J Waruk, M Sharma, TB Ball

The International Journal of Tuberculosis and Lung Disease | Published : 2016

Abstract

BACKGROUND: Several studies have shown polymorphisms within the interferon-gamma (IFN-) promoter influence cytokine expression. The interferon-gamma release assay (IGRA) relies on the ability to produce IFN- in response to tuberculosis (TB) specific antigens. This study determined the relationship between the IFN- +874 A/T promoter polymorphism and the performance of the QuantiFERON-TB Gold In-Tube (QFT-GIT) test in an ethnically diverse Canadian population. METHODS: A total of 190 participants were categorised into three groups based on history of and exposure to TB: active TB (n = 55), TB exposed (n = 55) and presumably TB unexposed controls (n = 80). All participants underwent QFT-GIT tes..

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University of Melbourne Researchers

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