Granulocyte colony-stimulating factor and reproductive medicine: A review.
Marcelo Borges Cavalcante, Fabrício DA Silva Costa, Ricardo Barini, E Araujo Júnior
International Journal of Reproductive BioMedicine (IJRM) | Published : 2015
BACKGROUND: Recently, the use of granulocyte colony-stimulating factor (G-CSF) has been proposed to improve pregnancy outcomes in reproductive medicine. OBJECTIVE: A systematic review of the current use of G-CSF in patients who have difficulty conceiving and maintaining pregnancy was performed. MATERIALS AND METHODS: Two electronic databases (PubMed/ Medline and Scopus) were searched. Study selection, data extraction and quality assessment were performed in duplicate. The subject codes used were granulocyte colony-stimulating factor, G-CSF, recurrent miscarriage, IVF failure, and endometrium. RESULTS: The search of electronic databases resulted in 215 citations (PubMed/ Medline: 139 and Scop..View full abstract