Journal article
Familial aggregation of albuminuria and arterial hypertension in an Aboriginal Australian community and the contribution of variants in ACE and TP53
DL Duffy, SP McDonald, B Hayhurst, S Panagiotopoulos, TJ Smith, XL Wang, DE Wilcken, NL Duarte, J Mathews, WE Hoy
BMC Nephrology | BMC | Published : 2016
Abstract
Background: Aboriginal Australians are at high risk of cardiovascular, metabolic and renal diseases, resulting in a marked reduction in life expectancy when compared to the rest of the Australian population. This is partly due to recognized environmental and lifestyle risk factors, but a contribution of genetic susceptibility is also likely. Methods: Using results from a comprehensive survey of one community (N = 1350 examined individuals), we have tested for familial aggregation of plasma glucose, arterial blood pressure, albuminuria (measured as urinary albumin to creatinine ratio, UACR) and estimated glomerular filtration rate (eGFR), and quantified the contribution of variation at four c..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
DLD was an NHMRC Senior Research Fellow. WH holds an Australia Fellowship. This study was supported by multiple organisations: NHMRC Project grant: Epidemiology and prevention of renal disease in Australian Aborigines - Part 1, APP921134. NHMRC Project grant: Family studies of renal disease, social, environmental and genetic causes, APP951250. NHMRC Project grant and Senior Research Fellowship: Epidemiology and prevention of renal disease in Australian Aborigines - Part 2, APP951342. The Colonial Foundation, Australia. NHMRC Australia Research Fellowship: Chronic Disease in High Risk Populations, APP511081. NHMRC Centre of Research Excellence: CRE in Chronic Kidney Disease in Australia, CKD. CRE, APP1079502. Funding bodies made no contributions to the design, collection, analysis, interpretation of data, writing of the manuscript and submission of the manuscript for publication.