Journal article

Characterization of the cellular and cytokine response in the central nervous system following Semliki Forest virus infection

MM Morris, H Dyson, D Baker, LS Harbige, JK Fazakerley, S Amor

JOURNAL OF NEUROIMMUNOLOGY | ELSEVIER SCIENCE BV | Published : 1997

Abstract

Cytokines are important mediators in the pathogenesis of central nervous system (CNS) inflammatory diseases including multiple sclerosis (MS), experimental allergic encephalomyelitis (EAE), viral encephalitis and virus induced demyelinating diseases. We have used immunohistochemical techniques to characterize the mononuclear cell infiltrate and cytokine profiles in the CNS following infection of mice with the demyelinating A7(74) strain of Semliki Forest virus (SFV), an important viral model of MS. Mononuclear cell infiltrates in the CNS, first observed at 3 days and maximal during clearance of infectious virus, were comprised predominantly of CD8+ lymphocytes. F4/80+ macrophage/microglia an..

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