Journal article

IN-VIVO DEPLETION OF CD8 T-CELLS PREVENTS LESIONS OF DEMYELINATION IN SEMLIKI FOREST VIRUS-INFECTION

I SUBAKSHARPE, H DYSON, J FAZAKERLEY

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 1993

Abstract

Following intraperitoneal infection of BALB/c mice with the A7(74) strain of Semliki Forest virus, the virus spreads to the central nervous system (CNS) and initiates an acute inflammatory reaction which includes lesions of primary demyelination. This demyelination is dependent upon activated T lymphocytes. To determine whether CD4+ or CD8+ T cells are involved in the pathogenesis of the demyelination, we have investigated the course of infection in animals treated with monoclonal anti-CD4 or anti-CD8 antibodies. In the normal course of infection, virus was detectable in the brain by infectivity assay and in situ hybridization for up to 14 days. Antiviral immunoglobulin M (IgM) and all subcl..

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