Journal article

CAN VIRAL ENVELOPE GLYCOLIPIDS PRODUCE AUTOIMMUNITY, WITH REFERENCE TO THE CNS AND MULTIPLE-SCLEROSIS

HE WEBB, JK FAZAKERLEY

Neuropathology and Applied Neurobiology | BLACKWELL SCIENCE LTD | Published : 1984

Abstract

Many viruses, with lipid envelopes derived from the host cell membranes, have been implicated in the aetiology of multiple sclerosis (MS), and epidemiological studies support an infectious agent. Alternatively the disease is thought by other workers to be auto-immune in nature, and recently much attention has been focused on immunological sensitivity to glycolipids in MS patients. In this paper it is proposed that CNS demyelination could arise in susceptible individuals (HLA type) from an immune response to glycolipids, triggered by the carrier effect of one or more enveloped neurotropic viruses.