Journal article

REPRODUCIBILITY OF THE FIRST-PHASE INSULIN-RESPONSE TO INTRAVENOUS GLUCOSE IS NOT IMPROVED BY RETROGRADE CANNULATION AND ARTERIALIZATION OR THE USE OF A LOWER GLUCOSE DOSE

PD MCNAIR, PG COLMAN, FP ALFORD, LC HARRISON

Diabetes Care | AMER DIABETES ASSOC | Published : 1995

Abstract

OBJECTIVE: To determine whether the reproducibility of the first-phase insulin response (FPIR) measured during an intravenous glucose tolerance test is improved by the use of a lower glucose dose or retrograde sampling from an arterialized hand vein. RESEARCH DESIGN AND METHODS: Previous studies have suggested that the high within-subject variation of FPIR measurement of up to 110% could be reduced by sampling from a retrograde cannulated and arterialized hand vein opposite to the cubital fossa vein through which the glucose was injected or by the use of a lower dose of glucose. Two low-dose (glucose, 5 g/m2 injected over 30 s) and two standard Islet Cell Antibody Registry Users Study (ICARU..

View full abstract