Journal article

ANTIBODIES TO GLUTAMIC-ACID DECARBOXYLASE IN AT-RISK AND CLINICAL INSULIN-DEPENDENT DIABETIC SUBJECTS - RELATIONSHIP TO AGE, SEX AND ISLET-CELL ANTIBODY STATUS, AND TEMPORAL PROFILE

RS SCHMIDLI, HJ DEAIZPURUA, LC HARRISON, PG COLMAN

JOURNAL OF AUTOIMMUNITY | ACADEMIC PRESS LTD | Published : 1994

Abstract

Antibodies to glutamic decarboxylase (GADAb) are present in insulin-dependent diabetes (IDD) but their association with age and sex and their temporal profile in relation to disease onset have not been fully documented. We have examined the association between GADAb and islet cell antibodies (ICA), age and sex, and have cross-sectionally and longitudinally measured the levels of GADAb before and after diagnosis of IDD. GADAb were measured by allowing serum immunoglobulin prebound to protein A Sepharose to precipitate GAD enzymatic activity from a fetal pig brain extract. GADAb levels were above the normal range (mean + 3SD of healthy controls, 460 nU/ml) in 19/44 (43%) at-risk subjects (ICA ..

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