Journal article
IMPROVED SPECIFICITY OF ICA ASSAYS IN THE 4TH INTERNATIONAL-IMMUNOLOGY-OF-DIABETES-SERUM-EXCHANGE-WORKSHOP
CJ GREENBAUM, JP PALMER, S NAGATAKI, Y YAMAGUCHI, JL MOLENAAR, WAM VANBEERS, NK MACLAREN, A LERNMARK
DIABETES | AMER DIABETES ASSOC | Published : 1992
Abstract
The goal of the Fourth International Workshop for Standardization of ICA Measurements was to determine the specificity of ICA assays and their ability to distinguish between control sera (n = 57) and sera from IDDM-related individuals--representing relatives of IDDM patients (n = 21), healthy individuals who later developed IDDM (n = 8), or newly diagnosed IDDM patients (n = 23). Results from 28 laboratories were analyzed. The mean specificity (percentage of control sera reported as negative) among 27 laboratories was 91%, including 6 laboratories with 100% specificity. Nevertheless, 78% of laboratories found at least one control sample > 0 JDF U. Among samples from first-degree relatives, t..
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