Journal article

HIGH-LEVEL OF CONCORDANCE BETWEEN ASSAYS FOR GLUTAMIC-ACID DECARBOXYLASE ANTIBODIES - THE FIRST INTERNATIONAL GLUTAMIC-ACID DECARBOXYLASE ANTIBODY WORKSHOP

RS SCHMIDLI, PG COLMAN, E BONIFACIO, GF BOTTAZZO, LC HARRISON, A ARNAIZVILLENA, S BAEKKESKOV, C BETTERLE, E BOSI, M BOUANANI, M DELAMAIRE, T DYRBERG, G EISENBARTH, W HAGOPIAN, RL HUMBEL, D KAUFMAN, T KOBAYASHI, A LERNMARK, RDG LESLIE, M MARSHALL Show all

Diabetes | AMER DIABETES ASSOC | Published : 1994

Abstract

Glutamic acid decarboxylase antibodies (GADAbs) are being increasingly used in clinical and research programs for the prediction and classification of insulin-dependent diabetes mellitus (IDDM). A number of different assay formats for the measurement of GADAbs have been reported, but the degree of concordance between assays is unknown. In this study, GADAbs were measured on 16 coded sera in 34 assays to examine concordance between GADAb assays and establish the feasibility of an international GADAb standard of measurement unit. The 16 lyophilized coded samples consisted of sera from healthy control subjects (n = 2), IDDM patients (n = 3), a patient with polyendocrine autoimmunity (n = 1), an..

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