Journal article
Reproducibility of estimating first phase insulin responses to intravenous glucose
M Koschmann, FP Alford, GM Ward, J Walters, PG Colman, LC Harrison
Diabetes Nutrition and Metabolism Clinical and Experimental | EDITRICE KURTIS S R L | Published : 1992
Abstract
Recent studies have questioned the reproducibility of first phase insulin response (FPIR) to intravenous glucose. The aim of the present study was to determine the variation of FPIR to intravenous glucose employing the following criteria: 1) the effect of single cannulation on estimating FPIR (between-arm study), 2) the reproducibility of FPIR when measured in the same individual on separate days (between-day study) and 3) the analysis of quantifying FPIR using four different mathematical methods i.e. 1+3 min insulin, mean Δ 3-5 min insulin, Δ 0-10 min insulin and Δ 0-10 min insulin corrected for Δ 0-10 min glucose. Ten normal individuals underwent two intravenous glucose tolerance tests (IV..
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