Journal article

INSULIN AUTOANTIBODIES IN PATIENTS WITH AUTOIMMUNE-DISEASES

M HARROP, J CAUDWELL, C STOJANOVSKI, PG COLMAN

Diabetes Research and Clinical Practice | ELSEVIER SCI IRELAND LTD | Published : 1992

Abstract

Insulin antibodies (IAA) can be detected in the serum of the majority of newly diagnosed IDDM patients prior to insulin therapy. In first degree relatives of IDDM patients, IAA are associated with an increased risk of development of IDDM. However, the disease specificity of IAA, detected by radiobinding assays, has not been addressed. We thus tested sera from patients with autoimmune disease for IAA. One of 29 (3%) patients with Graves' disease and five of 27 (19%) patients with SLE had IAA levels exceeding the range for normal controls. IAA were not detected in sera from 29 patients with Addison's disease, 15 patients with pernicious anaemia or 10 patients with increased gamma globulins. No..

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