Journal article

DISEASE SENSITIVITY AND SPECIFICITY OF 52 ASSAYS FOR GLUTAMIC-ACID DECARBOXYLASE ANTIBODIES - THE 2ND INTERNATIONAL GADAB WORKSHOP

RS SCHMIDLI, PG COLMAN, E BONIFACIO

Diabetes | AMER DIABETES ASSOC | Published : 1995

Abstract

There is increasing interest in the use of glutamic acid decarboxylase antibodies (GADAbs) for identification of subjects at increased risk of developing insulin-dependent diabetes mellitus (IDDM). However, considerable variation exists between laboratories in the reported frequency of GADAb in various clinical situations, and disease sensitivity and specificity have not yet been compared between assays. An international workshop was held in which 101 coded freeze-dried sera, including 39 from subjects with newly diagnosed IDDM, 32 from healthy control subjects, 4 from nondiabetic subjects with Graves' disease, and 4 from islet cell antibody-positive subjects, were analyzed in 52 assays (rad..

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