Journal article

Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non Communicable Medical Comorbidities

Anastasiya Slyepchenko, Michael Maes, Felice N Jacka, Cristiano A Koehler, Tatiana Barichello, Roger S McIntyre, Michael Berk, Iria Grande, Jane A Foster, Eduard Vieta, Andre F Carvalho

Psychotherapy and Psychosomatics | KARGER | Published : 2017

Abstract

BACKGROUND: Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hypothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and resultant bacterial translocation add a new element to the bidirectional interactions of the gut-brain axis; new evidence implicates these pathways in the patho-aetiology of MDD. In addition, abnormalities in the gut-brain axis are associated with several chronic non-communicable disorders, which frequently co-occur in individuals with MDD, including but not limited to irritable bowel syndrome (IBS), chronic fatigu..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship


Awarded by Juan Rodes research contract at the Instituto de Salud Carlos III, Spanish Ministry of Economy and Competiveness, Barcelona (Spain)


Awarded by CIBERSAM


Awarded by Grups Consolidats de Recerca


Funding Acknowledgements

C.A.K. is supported by a postdoctoral research fellowship from CAPES (Brazil). M.B. is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (1059660). I.G. has received a Juan Rodes research contract (JR15/00012) at the Instituto de Salud Carlos III, Spanish Ministry of Economy and Competiveness, Barcelona (Spain). E.V. thanks the Instituto de Salud Carlos III, Spanish Ministry of Economy and Competiveness, CIBERSAM (PI12/00912), the Grups Consolidats de Recerca 2014 (SGR 398), the Seventh European Framework Programme (ENBREC), and the Stanley Medical Research Institute for their support. A.F.C. is supported by a research fellowship award from CNPq (Brazil).