Journal article
Genetic factors contribute more to hip than knee surgery due to osteoarthritis – a population-based twin registry study of joint arthroplasty
K Magnusson, K Scurrah, E Ystrom, RE Ørstavik, T Nilsen, A Steingrímsdóttir, P Ferreira, AM Fenstad, O Furnes, KB Hagen
Osteoarthritis and Cartilage | ELSEVIER SCI LTD | Published : 2017
Abstract
Objective To explore and quantify the relative strengths of the genetic contribution vs the contribution of modifiable environmental factors to severe osteoarthritis (OA) having progressed to total joint arthroplasty. Design Incident data from the Norwegian Arthroplasty Registry were linked with the Norwegian Twin Registry on the National ID-number in 2014 in a population-based prospective cohort study of same-sex twins born 1915–60 (53.4% females). Education level and height/weight were self-reported and Body Mass Index (BMI) calculated. The total follow-up time was 27 years for hip arthroplasty (1987–2014, 424,914 person-years) and 20 years for knee arthroplasty (1994–2014, 306,207 person-..
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Funding Acknowledgements
We declare no conflicts of interests, except for Dr. Scurrah reporting grants from the National Health and Medical Research Council (Australia), during the conduct of the study.