Plasma Cortisol, Brain Amyloid-beta, and Cognitive Decline in Preclinical Alzheimer's Disease: A 6-Year Prospective Cohort Study
Robert H Pietrzak, Simon M Laws, Yen Ying Lim, Sophie J Bender, Tenielle Porter, James Doecke, David Ames, Christopher Fowler, Colin L Masters, Lidija Milicic, Stephanie Rainey-Smith, Victor L Villemagne, Christopher C Rowe, Ralph N Martins, Paul Maruff
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging | ELSEVIER | Published : 2017
BACKGROUND: Hypothalamic-pituitary-adrenal axis dysregulation, which is typically assessed by measuring cortisol levels, is associated with cognitive dysfunction, hippocampal atrophy, and increased risk for mild cognitive impairment and Alzheimer's disease (AD). However, little is known about the role of hypothalamic-pituitary-adrenal axis dysregulation in moderating the effect of high levels of amyloid-β (Aβ+) on cognitive decline in the preclinical phase of AD, which is often protracted, and thus offers opportunities for prevention and early intervention. METHODS: Using data from a 6-year multicenter prospective cohort study, we evaluated the relation between Aβ level, plasma cortisol leve..View full abstract
Awarded by NHMRC Australia
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study was supported in part by the study partners (Commonwealth Scientific Industrial and Research Organization, Edith Cowan University, Mental Health Research institute, National Ageing Research Institute, Austin Health, CogState Ltd.). The study also was supported by the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program; the Science and Industry Endowment Fund; Cooperative Research Centre for Mental Health; the NHMRC Australia by a project grant (Grant No. APP1009292 to SML and RNM); the Cooperative Research Centre for Mental Health, an Australian Government Initiative, and the Clinical Neurosciences Division of the U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder.