Journal article
Midazolam-Droperidol, Droperidol, or Olanzapine for Acute Agitation: A Randomized Clinical Trial
DMD Taylor, CYL Yap, JC Knott, SE Taylor, GA Phillips, J Karro, EW Chan, DCM Kong, DJ Castle
Annals of Emergency Medicine | Published : 2017
Abstract
Study objective We aim to determine the most efficacious of 3 common medication regimens for the sedation of acutely agitated emergency department (ED) patients. Methods We undertook a randomized, controlled, double-blind, triple-dummy, clinical trial in 2 metropolitan EDs between October 2014 and August 2015. Patients aged 18 to 65 years and requiring intravenous medication sedation for acute agitation were enrolled and randomized to an intravenous bolus of midazolam 5 mg–droperidol 5 mg, droperidol 10 mg, or olanzapine 10 mg. Two additional doses were administered, if required: midazolam 5 mg, droperidol 5 mg, or olanzapine 5 mg. The primary outcome was the proportion of patients adequatel..
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Funding Acknowledgements
By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The authors have stated that no such relationships exist. The study was supported by the Morson Taylor Research Award 2013 of the Australasian College for Emergency Medicine Foundation and the Austin Health Medical Research Foundation, 2014.