Journal article
Panoramic characterization of endocardial left atrial activation during human persistent AF: Insights from non-contact mapping
G Lee, AJA McLellan, RJ Hunter, MJ Lovell, M Finlay, W Ullah, MB Dhinoja, S Sporton, MJ Earley, RJ Schilling
International Journal of Cardiology | ELSEVIER IRELAND LTD | Published : 2017
Abstract
Background The relative importance of focal drivers, multiple wavelets, rotors and endocardial–epicardial circuits in the maintenance of persistent AF remains unclear. Our objective was to characterize AF wavefront (WF) dynamics during persistent AF. Methods The Ensite 3000 (St Jude Medical) non-contact mapping system was used to map the LA of 15 patients with persistent AF. Wavefronts were classified into planar WFs, rotors or focal WFs. For each new WF the site of origin, the unipolar electrogram, and propagation patterns were determined. Results AF was characterized by highly unstable patterns of activation with random combinations of 1–2 propagating planar wavefronts alternating with foc..
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Funding Acknowledgements
Dr. Schilling has received research funding and research fellow support from Biosense Webster, Inc., and Drs Sporton, M.J. Earley, and W. Ullah have received lecturing honoraria from Biosense Webster, Inc. Dr. McLellan is supported by an Endeavour Fellowship from the Australian Government, a fellowship grant from the European Heart Rhythm Association, and has received research support from St Jude Medical. Dr. Lee is supported by the Neil Hamilton Fairley Scholarship from the National Health and Medical Research Council of Australia.