Journal article

The Effector Cig57 Hijacks FCHO-Mediated Vesicular Trafficking to Facilitate Intracellular Replication of Coxiella burnetii

Eleanor A Latomanski, Patrice Newton, Chen Ai Khoo, Hayley J Newton

PLOS PATHOGENS | PUBLIC LIBRARY SCIENCE | Published : 2016

Abstract

Coxiella burnetii is an intracellular bacterial pathogen that infects alveolar macrophages and replicates within a unique lysosome-derived vacuole. When Coxiella is trafficked to a host cell lysosome the essential Dot/Icm type IV secretion system is activated allowing over 130 bacterial effector proteins to be translocated into the host cytosol. This cohort of effectors is believed to manipulate host cell functions to facilitate Coxiella-containing vacuole (CCV) biogenesis and bacterial replication. Transposon mutagenesis has demonstrated that the Dot/Icm effector Cig57 is required for CCV development and intracellular replication of Coxiella. Here, we demonstrate a role for Cig57 in subvert..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This research was financially supported by project grants 1062383 and 1063646 awarded to HJN by the National Health and Medical Research Council of Australia. EAL is supported by an Australian Postgraduate Award. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.