Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis
KR Palmer, S Tong, TJ Kaitu'u-Lino
MOLECULAR HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2017
Pre-eclampsia is a common obstetric complication globally responsible for a significant burden of maternal and perinatal morbidity and mortality. Central to its pathophysiology is the anti-angiogenic protein, soluble fms-like tyrosine kinase-1 (sFLT-1). sFLT-1 is released from a range of tissues into the circulation, where it antagonizes the activity of vascular endothelial growth factor and placental growth factor leading to endothelial dysfunction. It is this widespread endothelial dysfunction that produces the clinical features of pre-eclampsia including hypertension and proteinuria. There are multiple splice variants of sFLT-1. One, known as sFLT-1 e15a, evolved quite recently and is onl..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
Funded by National Health and Medical Research Council (NHMRC) grants (# 1101871, # 1061977). NHMRC also provided salary support (# 1050765 to S.T. # 1062418 to T.J.K.). K.R.P. received salary support from the Department of Obstetrics and Gynaecology, Monash University.