Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis

KR Palmer; S Tong; TJ Kaitu'u-Lino

Journal article

Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis

KR Palmer, S Tong, TJ Kaitu'u-Lino

MOLECULAR HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2017

DOI: 10.1093/molehr/gaw077

Abstract

Pre-eclampsia is a common obstetric complication globally responsible for a significant burden of maternal and perinatal morbidity and mortality. Central to its pathophysiology is the anti-angiogenic protein, soluble fms-like tyrosine kinase-1 (sFLT-1). sFLT-1 is released from a range of tissues into the circulation, where it antagonizes the activity of vascular endothelial growth factor and placental growth factor leading to endothelial dysfunction. It is this widespread endothelial dysfunction that produces the clinical features of pre-eclampsia including hypertension and proteinuria. There are multiple splice variants of sFLT-1. One, known as sFLT-1 e15a, evolved quite recently and is onl..

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University of Melbourne Researchers

Tu'uhevaha Kaitu'u-Lino Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Stephen Tong Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Kirsten Palmer Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

Funded by National Health and Medical Research Council (NHMRC) grants (# 1101871, # 1061977). NHMRC also provided salary support (# 1050765 to S.T. # 1062418 to T.J.K.). K.R.P. received salary support from the Department of Obstetrics and Gynaecology, Monash University.