Journal article

The association of fecal microbiota and fecal, blood serum and urine metabolites in myalgic encephalomyelitis/chronic fatigue syndrome

Christopher W Armstrong, Neil R McGregor, Donald P Lewis, Henry L Butt, Paul R Gooley

Metabolomics | Springer Verlag | Published : 2017

Abstract

Introduction: The human gut microbiota has the ability to modulate host metabolism. Metabolic profiling of the microbiota and the host biofluids may determine associations significant of a host–microbe relationship. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a long-term disorder of fatigue that is poorly understood, but has been linked to gut problems and altered microbiota. Objectives: Find changes in fecal microbiota and metabolites in ME/CFS and determine their association with blood serum and urine metabolites. Methods: A workflow was developed that correlates microbial counts with fecal, blood serum and urine metabolites quantitated by high-throughput 1H NMR spec..

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Grants

Awarded by Judith Jane Mason and Harold Stannett Williams Memorial Foundation (The Mason Foundation)


Funding Acknowledgements

This work was supported by Grants from the Judith Jane Mason and Harold Stannett Williams Memorial Foundation (The Mason Foundation) CT9957 and MAS2015F020 and equipment Grants from the Rowden White foundation and State of Victoria.