Journal article

Insane in the membrane: a structural perspective of MLKL function in necroptosis

Emma J Petrie, Joanne M Hildebrand, James M Murphy

IMMUNOLOGY AND CELL BIOLOGY | NATURE PUBLISHING GROUP | Published : 2017

Abstract

Necroptosis (or 'programmed necrosis') is a caspase-independent cell death pathway that operates downstream of death receptors, including Tumour Necrosis Factor Receptor-1 (TNFR1), and the Toll-like receptors, TLR3 and TLR4. Owing to its immunogenicity, necroptosis has been attributed roles in the pathogenesis of several diseases, including inflammatory bowel disease and the tissue damage arising from ischaemic-reperfusion injuries. Only over the past 7 years has the core machinery of this pathway, the receptor-interacting protein kinase-3 (RIPK3) and the pseudokinase, Mixed Lineage Kinase domain-Like (MLKL), been defined. Our current understanding of the pathway is that RIPK3-mediated phosp..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

Some of the studies reviewed herein were enabled by support from the National Health and Medical Research Council of Australia (Projects 1057905, 1067289 and Fellowship 1105754 to JMM; Project 1105023 to JMH; IRIISS 9000220) and the Victorian Government Operational Infrastructure Support.