Journal article

Modelling the effect of short-course multidrug-resistant tuberculosis treatment in Karakalpakstan, Uzbekistan

James M Trauer, Jay Achar, Nargiza Parpieva, Atadjan Khamraev, Justin T Denholm, Dennis Falzon, Ernesto Jaramillo, Anita Mesic, Philipp du Cros, Emma S McBryde

BMC Medicine | BIOMED CENTRAL LTD | Published : 2016

Abstract

BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is a major threat to global TB control. MDR-TB treatment regimens typically have a high pill burden, last 20 months or more and often lead to unsatisfactory outcomes. A 9-11 month regimen with seven antibiotics has shown high success rates among selected MDR-TB patients in different settings and is conditionally recommended by the World Health Organization. METHODS: We construct a transmission-dynamic model of TB to estimate the likely impact of a shorter MDR-TB regimen when applied in a low HIV prevalence region of Uzbekistan (Karakalpakstan) with high rates of drug resistance, good access to diagnostics and a well-established community-..

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Grants

Funding Acknowledgements

The authors thank the Ministry of Health, Uzbekistan, and the National TB Institute of Tashkent, Uzbekistan, for their support. James Trauer is supported by a Monash University Bridging Fellowship. DF and EJ are WHO staff; they alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions or policies of WHO. The designations used and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of WHO concerning the legal status of any country, territory, city or area, or of its authorities, nor concerning the delimitation of its frontiers or boundaries.