Journal article

Vaginal wall weakness in parous ewes: a potential preclinical model of pelvic organ prolapse

Natharnia Young, Anna Rosamilia, John Arkwright, Joseph Lee, Miranda Davies-Tuck, Joan Melendez, Jerome Werkmeister, Caroline E Gargett



INTRODUCTION AND HYPOTHESIS: Ewes develop pelvic organ prolapse (POP) and may be a suitable model for preclinical studies evaluating cell-based therapies for POP. The aim of this study was to establish a clinical score of vaginal weakness and to compare POP Quantification System (POP-Q) values in conscious nulliparous and parous ewes and determine whether ewes are a suitable POP model. METHODS: Ewes (n = 114) were examined while conscious, without sedation, and standing in a V conveyer by adapting the human POP-Q measurement. Ovine POP was defined as descent to the introitus from POP-Q points Aa 3 cm above the introitus on the anterior wall, Ap 3 cm above the introitus on the posterior wall,..

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Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC

Funding Acknowledgements

This work was support by the National Health and Medical Research Council (NHMRC) of Australia Project grants # 1021126 (CEG, JAW, AR), #1081944 (CEG, JAW, JA, AR), a NHMRC Senior Research Fellowship (1042298) (CEG) and from the Victorian Government's Operational Infrastructure Support Program.