Effects of Bariatric Surgery on Liver Function Tests in Patients with Nonalcoholic Fatty Liver Disease

GJ Ooi; PR Burton; L Doyle; JM Wentworth; PS Bhathal; K Sikaris; MA Cowley; SK Roberts; W Kemp; A Earnest; PE O’Brien; WA Brown

Journal article

Effects of Bariatric Surgery on Liver Function Tests in Patients with Nonalcoholic Fatty Liver Disease

GJ Ooi, PR Burton, L Doyle, JM Wentworth, PS Bhathal, K Sikaris, MA Cowley, SK Roberts, W Kemp, A Earnest, PE O’Brien, WA Brown

Obesity Surgery | SPRINGER | Published : 2017

DOI: 10.1007/s11695-016-2482-8

Abstract

Objectives: Nonalcoholic fatty liver disease (NAFLD) affects over 80% of obese patients and is fueled by the metabolic syndrome. Weight loss is strongly advocated as a central treatment for NAFLD and has been shown to induce histological improvement. We aimed to define the patterns of improvement in NAFLD with weight loss and determine target weight goals for NAFLD resolution. Methods: A prospective study of 84 morbidly obese patients with NAFLD undergoing bariatric surgery was conducted. Intraoperative liver biopsies were taken. Monthly follow-up, including blood tests and measurements, was performed. We monitored improvements in NAFLD by monthly alanine aminotransferase (ALT) and gamma glu..

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University of Melbourne Researchers

John Wentworth Author

Grants

Funding Acknowledgements

We acknowledge the kind support of the Royal Australasian College of Surgeons and the National Health and Medical Research Council in supporting Dr. Ooi and Dr. Doyle in their higher degrees and in completing this research.