Journal article
A Phosphorylcholine-Containing Glycolipid-like Antigen Present on the Surface of Infective Stage Larvae of Ascaris spp. Is a Major Antibody Target in Infected Pigs and Humans
Johnny Vlaminck, Dries Masure, Tao Wang, Peter Nejsum, Cornelis H Hokke, Peter Geldhof
PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
BACKGROUND: The pig parasite Ascaris suum plays and important role in veterinary medicine and represents a suitable model for A. lumbricoides, which infects over 800 million people. In pigs, continued exposure to Ascaris induces immunity at the level of the gut, protecting the host against migrating larvae. The objective of this study was to identify and characterize parasite antigens targeted by this local immune response that may be crucial for parasite invasion and establishment and to evaluate their protective and diagnostic potential. METHODOLOGY/PRINCIPAL FINDINGS: Pigs were immunized by trickle infection for 30 weeks, challenged with 2,000 eggs at week 32 and euthanized two weeks afte..
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Funding Acknowledgements
The Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT) funded the work of JV. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.