Journal article

EXPERIMENTAL PROCTITIS DUE TO RECTAL INFECTION WITH CHLAMYDIA-TRACHOMATIS IN NONHUMAN-PRIMATES

TC QUINN, HR TAYLOR, J SCHACHTER

The Journal of Infectious Diseases | UNIV CHICAGO PRESS | Published : 1986

Abstract

To serially examine the immunopathogenesis and histopathology of rectal infection with Chlamydia trachomatis, we inoculated five cynomolgus monkeys with C. trachomatis serovar E (non-LGV) and five with serovar L2 (LGV). After inoculation, C. trachomatis was isolated from rectal cultures in three of five non-LGV-infected monkeys and in all five LGV-infected monkeys for a period of 10 weeks. LGV-infected monkeys developed a severe hemorrhagic ulcerative proctitis, in contrast to a mild proctitis in the non-LGV-infected monkeys. Hyperplasia of lymphoid follicles and a mucosal polymorphonuclear leukocyte and mononuclear cell infiltrate were evident in all infected monkeys. Crypt abscesses with g..

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