Journal article

EFFECT OF SINGLE-DOSE INVERMECTIN THERAPY ON HUMAN ONCHOCERCA-VOLVULUS INFECTION WITH ONCHOCERCAL OCULAR INVOLVEMENT

HS NEWLAND, AT WHITE, BM GREENE, SA DANNA, E KEYVANLARIJANI, MA AZIZ, PN WILLIAMS, HR TAYLOR

British Journal of Ophthalmology | BRITISH MED JOURNAL PUBL GROUP | Published : 1988

Abstract

Ivermectin has shown promise as a potentially safe and effective microfilaricidal drug for the treatment of onchocerciasis. Several limited studies have shown it to have fewer side effects, especially ocular complications, than the currently available drug, diethylcarbamazine. The detailed ocular findings in 200 moderately to heavily infected Liberians who were enrolled in a safety and dose-finding study are presented. They received either 0, 100, 150, or 200 micrograms/kg of ivermectin and were followed up for 12 months. In clinical studies so far carried out ivermectin in a dose of 100, 150, or 200 micrograms/kg has not been associated with any major adverse reactions nor were there any si..

View full abstract